THE PIVOTALITY OF HEMOSTATS & TISSUE SEALANTS
Originally, Hemostats were designed in such a way as to clamp the small blood vessels for hemorrhage control. Another use of this is to grasp & secure the superficial fascia during the debriding and undermining of wounds. Finally, this instrument is regarded as one of the excellent tools for exploring, exposing, and visualizing the deeper areas of the wound. In 2020, the overall valuation of the Global Hemostats & Tissue Sealants Market was around USD 6.35 billion. As per the SMR analysis, the market is expected to reach a solid benchmark of around USD 11.27 billion by 2030, projecting a CAGR of nearly 8.93 % over the forecasted period.
The Coagulation system comprises proteins & blood cells that are responsible for blood clots leading to platelet plug formation, hemostasis, etc. The tremendous growth in the market is expected because of the rising number of surgeries around the world. Immune Thrombocytopenia or Hemophilia is a disorder where the blood doesn’t clot in a typical way. Hemophilia type A adversely impacts one out of 5,000 male children, & in the USA, the (Hemophilia A) disease affects around 400 babies annually.
The CDC (Centers for Disease Control and Prevention (CDC)) asserted that more than 45% of the population in the USA suffers from at least one chronic disease that requires proper care. Every year, nearly 2 Mn people die due to hemorrhage worldwide, out of which almost 1.5 Mn deaths are caused due to physical trauma. However, in the United States, nearly 60,000 people die due to hemorrhaging & blood loss each year.
The various kinds of Hemostats that are prevailing in the current market are as follows:
a.) Topical Hemostats
Topical Hemostats are widely used in the setting of surgeries or trauma that adheres to maintaining the hemostasis process. Topical hemostat products involve collagens, fibrin sealants, gelatine sponges, and active thrombin preparations. These agents are applied locally to restrict blood flow.
b.) Mechanical Hemostats
Mechanical hemostats are widely applied as sponges & it doesn’t contain thrombin or any other sort of active biologic compounds. They produce swelling & cause a mechanical barrier to the bleeding & oozing. They can also be used along with thrombin or saline & are stored at a normal room temperature. These products can also lead to abscess formation.
c.) Polysaccharide based Hemostats
The development of hemostatic products because of the polysaccharides for their promising applications in wound healing is of immense biomedical and academic interest worldwide. This comprehensive review represents the most significant advancements in the field of polysaccharide-based hemostats for the decade regarding their advantages and limitations, hemostatic mechanisms, & the factors influencing the efficacy. The primary focus is given on the progress in naturally derived polysaccharides like chitosan, starch, alginate, cellulose, hyaluronic acid, dextran, and their derivatives for their hemostasis in the wound healing process.
CONCLUSION
Thus due to the advent of these highly developed hemostats, the market is poised to grow exponentially in the upcoming years. Moreover, governments across the world are also investing a hefty sum of money in the technological developments of hemostats and tissue sealants along with their way of installation.
